Lilly Advocate Program
Location: Room 220ABC

Latin America Breast Cancer Association (LABCA)
Location: Room 301ABC

(All times are in Central Standard Time)

Trainee Workshop: Enhanced Research and Community Impact
Location: 221ABC

Special Session 1 - Open Bar and All you Can Eat? The Impact of Lifestyle in Breast Cancer Risk and Recurrence

Location: Stars at Night 1 & 2

Moderator: Seema Khan, MD, MS, Northwestern University Feinberg School of Medicine, Chicago

11:00 AM - 11:25 AM - Topic 1: Alcohol, genetics of alcohol metabolism and breast cancer risk

• Julia Palmer, ScD, Boston University, Boston

11:25 AM - 11:55 AM - Topic 2: Effects of alcohol consumption and cessation on breast cancer risk

• Mary Beth Terry, PhD, Columbia University, New York

11:55 AM - 12:15 PM - Topic 3: Obesity and Breast Cancer- the molecular link

• Kristy Brown, PhD, University of Kansas Medical Center, Kansas City, Kansas

Patient Advocate: Stacey Tinianov, MPH, BCPA, Advocates for Collaborative Education, Santa Cruz, California

12:15 PM - 12:30 PM  Panel Q&A

Special Session 2: Lobular Breast Cancer Updates
Location: Stars at Night 3 & 4

Moderator: Steffi Oesterreich, PhD, UPMC Hillman Cancer Center, Pittsburgh & Marleen Kok, MD, PhD, Netherlands Cancer Institute, Amsterdam

11:10 AM - 11:25 Topic 1: Current updates on diagnostic criteria and classification of special subtypes

• Anne Vincent-Salomon, PhD, Institut Curie, Paris

11:25 AM - 11:40 AM Topic 2: Novel biomarkers with clinical implications

• Christos Sotiriou, MD, PhD, Institut Jules Bordet, Anderlecht, Belgium

11:40 AM - 11:55 AM Topic 3: Controversies in clinical decision making – is there still a role for chemotherapy?

• Otto Metzger, MD, Dana-Farber Cancer Institute, Boston

11:55 AM - 12:10 PM Topic 4: LC-specific trials: lessons learned and future designs

• Philipe Aftimos, MD, Insitut Jules Bordet, Anderlecht, Belgium

12:10 PM - 12: 30 PM Panel discussion

Patient Advocate: Flora Migyanka, BA, Dynami Foundation

Special Session 3: Breast Cancer in Young Women: Biology, Treatment, and Ethics
Location: Hemisfair Ballroom 1-2

Moderator: Ann Partridge, MD, MPH, Dana-Farber Cancer Institute, Boston

11:00 AM - 11:30 AM Topic 1: Epidemiology and Biology of Young Onset Breast Cancer

• Virginia Borges, MD, UCHealth Diane O’Connor Thompson Breast Center – Anschutz Medical Campus, Aurora, Colorado

11:30 AM - 12:00 PM Topic 2: Special Management Considerations for Young Patients with Breast Cancer

• Yara Abdou, MD, MSCR, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

12:00 PM - 12:30 PM Topic 3: Ethical Issues in the Care of Young Patients with Breast Cancer

• Lisa Campo-Engelstein, PhD, University of Texas Medical Branch, Galveston, Texas

Translational Workshop 1: Spatial Omics for Prediction, Prognostication, and Mechanistic Insights
Location: Stars at Night 1-2

Moderator: Leif Ellisen, MD, PhD, Harvard University, Cambridge, Massachusetts

12:45 PM -1:10 PM Topic 1: Proteomics

• Sandro Santagata, MD, PhD, Harvard Medical School, Cambridge, Massachusetts

1:10 PM - 1:35 PM Topic 2: Metabolomics+

• Ralph Deberardinis, MD, PhD, UT Southwestern, Dallas

1:35 PM - 2:00 PM Topic 3: Gylcocomics

• TBD

2:00 PM - 2:15 PM Panel discussion

 Patient Advocate: Jane Perlmutter, PhD, Independent Patient Advocate

Translational Workshop 2: Liquid Biopsy in Breast Cancer, Bridging Technology and Clinical Practice
Location: Stars at Night 3-4

Moderator: Pedram Razavi, MD, PhD, Memorial Sloan Kettering Cancer Center, New York

12:45 PM - 1:10 PM Topic 1: Emerging technologies in liquid biopsy

• Maximilian Diehn, MD, PhD, Stanford University, Stanford, California

1:10 PM - 1:35 PM Topic 2: Expanding clinical application of liquid biopsy in breast cancer

• Pedram Razavi, MD, PhD, Memorial Sloan Kettering Cancer Center, New York 

1:35 PM - 2:00 PM Topic 3: Utilizing liquid biopsy for detection and monitoring CNS metastases

• Alexandra Miller, MD, PhD, NYU Langone Health Perlmutter Cancer Center, New York

2:00 PM - 2:15 PM Panel discussion

Patient Advocate: Michelle Tregear, National Breast Cancer Coalition

Clinical Workshop 1: Risk Assessment and Management in Young Women
Location: Hemisfair Ballroom 1-2

12:45 PM - 12:55 PM Moderator: Sonya Reid, MD, MPH, Vanderbilt-Ingram Cancer Center, Nashville

12:55 PM - 1:10 PM Topic 1: Surveillance strategies for young women – when and how often?

• Allison Kurian, MD, M.Sc, Stanford Medicine, Stanford, California

1:10 PM - 1:25 PM Topic 2: Novel imaging strategies for young women – looking to the future

• Emily Conant, MD, University of Pennsylvania Perelman School of Medicine, Philadelphia

1:25 PM - 1:40 PM Topic 3: Should management of atypia in young women differ?

• Laura K. Harper, Mayo Clinic, Phoenix, Arizona

1:40 PM - 1:55 PM Topic 4: Considerations for Prevention – balancing fertility and risk

• Seema Kahn, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago

1:55 PM - 2:15 PM Panel discussion

Patient Advocate: Vernal Branch, Independent Research Patient Advocatie, Richmond, Virginia

Careeer Development: Compassionate Leadership Workshop
Location: 221ABC

Speaker: Anne Welsh

Educational Session 1: After CDK4/6 Inhibitors: Advancing Treatment for HR+HER2-negative Metastatic Breast Cancer
Location: Stars at night 1-2

Moderator: Antoinette Tan, MD, MHS, Wake Forest University School of Medicine, Charlotte, North Carolina

2:30 PM - 3:00 PM Topic 1: Treatment Strategies after CDK4/6 Inhibitor Progression

• Mafalda Oliveira, MD, PhD, Vall d'Hebron Hospital, Barcelona

3:00 PM - 3:30 PM Topic 2: Next Generation Endocrine Agents

• Erica Mayer, MD, MPH, Dana-Farber Cancer Institute, Boston

3:30 PM - 4:00 PM Topic 3: Emerging Agents to Overcome CDK4/6 Inhibitor Resistance

• Shom Goel, PhD, FRACP, Peter MacCallum Cancer Centre, Melbourne, Australia

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Abigail Johnston, SurvivingBreastCancer.org, Orlando, Florida

Educational Session 2: Dormancy and Re-activation of Breast Cancer Cells at Distant Metastatic Sites
Location: 221 ABC

Moderator: Heide Ford, PhD, University of Colorado School of Medicine, Denver

2:30 PM - 3:00 PM - Topic 1: Viral reactivation of dormant breast cancer

• Mercedes Rincon, PhD, University of Colorado School of Medicine, Aurora, Colorado

3:00 PM - 3:30 PM Topic 2: Role of alveolar macrophages in dormancy

• Xue-Yan He, PhD, Washington University in St. Louis

3:30 PM - 4:00 PM Topic 3: In vivo mechanisms regulating cellular dormancy and tumor recurrence

• Lewis Chodosh, PhD, University of Pennsylvania Perelman School of Medicine, Philadelphia

4:00 PM - 4:15 PM Panel Discussion

Patient Advocate: Lynda Weatherby, Metastatic Breast Cancer Alliance, Seattle

Educational Session 3: Refining Local Therapy in Multi-disciplinary Care
Location: Stars at Night 3-4

Moderator: Jonathan Strauss, MD, MBA, Roberts H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

2:30 PM - 3:00 PM Topic 1: Repeat Breast Conservation with reirradiation – what’s the data and how do we do it?

• Chelain Goodman, MD, PhD, MD Anderson Cancer Center, Houston

3:00 PM - 3:30 PM Topic 2: Should we irradiate the IM Nodes: Settling the Issue

• Birgitte Offersen, MD,  Aarhus University Department of Oncology, Aarhus, Denmark

3:30 PM - 4:00 PM Topic 3: The Truth About Radiotherapy and Reconstruction

• Justin Broyles, MD, Brigham and Women’s Hospital, Boston

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Judy Fitzgerald, Sisters4Prevention, Delray Beach, Florida

Educational Session 4: Balancing Act: Hormone Replacement Therapy in Breast Cancer Care
Location: Hemisfair Ballroom 1-2

Moderator: Tara Sanft, MD, Yale School of Medicine, New Haven, Connecticut

2:30 PM - 3:00 PM Topic 1: "HRT and Breast Cancer: How History Shaped Fear and What Comes Next" Re-examining past research, debunking myths, and guiding future recommendations

• Maryam Lustberg, MD, MPH, Yale School of Medicine, New Haven, Connecticut

3:00 PM - 3:30 PM Topic 2: "Navigating the Latest HRT Guidelines: What Leading Medical Societies Say" A comprehensive review of updated recommendations from major health organizations.

• Juliana Kling, MD, MPH, MACP, MSCP, Mayo Clinic, Phoenix

3:30 PM - 4:00 PM Topic 3: "HRT Across the Breast Cancer Spectrum: Risks, Benefits, and Considerations" Exploring HRT use in high-risk individuals, survivors, and different breast cancer subtypes.

• Lisa Larkin, MD, FACP, MSCP, Ms. Medicine/HERmedicine, Cincinnati, Ohio

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Thelma Perry Brown, BS, Patient Research Advocate, Birmingham, Alabama

Educational Session 5: Best of AACR
Location: Hemisfair Ballroom 3

2:30 PM - 2:50 PM Topic 1: The Influence of ecDNA in Cancer

2:50 PM - 3:10 PM Topic 2: State of RAS Inhibitor Field

3:10 PM - 3:30 PM Topic 3: Decoding the archetypes and ecotypes of triple-negative breast cancer in responses to chemotherapy

• Yun Yan, PhD Candidate, MD Anderson Cancer Center, Houston, Texas

3:30 PM - 3:50 PM Topic 4: An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer

• Kenichi Shimada, Harvart Medical School, Boston, Massachusetts

Rapid Fire 1
Location: Stars at Night 1-2

Rapid Fire 2
Location: Stars at Night 1-2

(All times are in Central Standard Time)

Poster Spotlight 1
Location: Hemisfair Ballroom 3

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30 - 7:50

Panel Q&A 1: 7:50 - 8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20 - 8:30

Poster Spotlight 2
Location: 301 ABC

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30 - 7:50

Panel Q&A 1: 7:50-8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20 - 8:30

Location: 302 ABC

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30 - 7:50

Panel Q&A 1: 7:50 - 8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20 - 8:30

Location: 221 ABC

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30-7:50

Panel Q&A 1: 7:50 - 8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20 - 8:30

Opening Remarks and McGuire Award
Location: Hall 1

• Opening Remarks from Symposium Co-Chairs Dr. Carlos Arteaga and Dr. Virginia Kaklamani
• McGuire Award presentation and lecture

General Session 1
Location: Hall 1

GS1-01 Speaker: Erika Hamilton, MD, FASCO, Sarah Cannon Research Institute, Nashville, Tennessee

GS1-02 Speaker: Charles E. Geyer Jr., MD, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

GS1-03 Discussant: Ciara O'Sullivan, M.B., B.Ch, Mayo Clinic, Rochester, Minnesota

GS1-04 Speaker: Matteo Lambertini, MD, PhD, University of Genova - IRCCS Ospedale Policlinico San Martino, Genoa, Italy

GS1-05 Speaker: Sunil Badve, MD, FRCPath, Emory School of Medicine, Atlanta, Georgia, USA

GS1-06 Speaker: Roberto Salgado, MD, PhD, Peter MacCallum Cancer Centre, Melbourne, Australia

GS1-07 Speaker: Antonio Llombart-Cussac, MD, PhD, Hospital Arnau de Villanova, Valencia, Spain

GS1-08 Discussant: Heather A. Parsons, MD, MPH, Dana-Farber Cancer Institute, Boston, Massachusetts

Exhibition Hall Open

Break

Clinical Case Discussion
Location: Stars at Night 1 & 2

Moderator: Hal Burstein, MD, PhD, Dana-Farber Cancer Institute, Boston

Panel members:

• William Gradishar, Feinberg School of Medicine, Northwester University, Chicago
• Olga Kantor, MD, MS, Dana-Farber Cancer Institute, Boston
• Hannah Yong Wen, MD, PhD, Memorial Sloan Kettering Cancer Center, New York 

Patient Advocate: Ginny Mason, Inflammatory Breast Cancer Research Foundation

Poster Session 1
Location: Exhibition Hall

State of the Art 1 - Refining Risk and Tailoring Treatment: Liquid Biopsy for Adaptive Therapy in Breast Cancer
Location: Stars at Night 1 & 2

1:00 PM - 1:10 PM Moderator: David Cescon, MD, Princess Margaret Cancer Centre, Toronto 

Topic 1: Neoadjuvant adaptive strategies: integrating imaging and ctDNA to personalize preoperative therapy

• Angie DeMichele, MD, MSCE, University of Pennsylvania Perelman School of Medicine, Philadelphia

Topic 2: MRD-Informed Adjuvant Therapy: From Risk Stratification to Personalized Management

• Michail Ignatiadis, MD, PhD, Institut Jules Bordet, Anderlecht, Belgium

Topic 3: Guiding Metastatic Breast Cancer Treatment with Dynamic and Predictive Liquid Biopsy Biomarkers

• François-Clément Bidard, MD, PhD, Institut Curie, Paris

Patient Advocate: Tracy Leduc Solak, 

Translational Controversies: : ADCs, Targeted Therapy or Chemo?
Location: Stars at Night 3 & 4

Moderator: David Rimm, MD, PhD, Yale School of Medicine, New Haven, Connecticut

1:05 - 1:25 Topic 1: HER2 low/ultralow; What the pathologist sees

• Dennis Sgroi, MD, Harvard University, Cambridge, Massachusetts

1:25 -1:45 Topic 2: Evidence that ADCs are target therapy

• Sarat Chandarlapaty, MD, PhD, Memorial Sloan Kettering Cancer Center, New York

1:45 - 2:05 Topic 3: Evidence that ADCs are chemotherapy

• Sara Hurvitz, MD, FACP, Fred Hutchinson Cancer Center, Seattle, Washington                

The Breast Cancer Family Registry: Past, Present, and Future
Location: 221ABC

Moderator: Mary Daly, MD, PhD, FACP, Fox Chase Cancer Center, Philadelphia, Pennsylvania

Topic 1: THe BCFR Cohorts: Genomics research across the breast cancer risk continuum

• Speaker TBD

Topic 2: Spatial molecular imaging and cell-free DNA analysis in the Northern California Breast Cancer Family Registry

• Speaker TBD

Topic 3: Risk prediction models for breast cancer integrating family history of breast/ovarian cancers and prophylactic interventions

• Speaker TBD

​​​​Topic 4: Prediction of second breast cancer events in the Breast Cancer Family Registry 

• Speaker TBD 

Educational Session 6: ADCs in the Clinic

Location: Stars at Night 1 & 2

Moderator: Adrienne Waks, MD, Dana-Farber Cancer Institute, Boston

2:30 PM - 3:00 PM Topic 1: Moving on up: ADCs in early - stage breast cancer

• Sibylle Loibl, MD, CEO of the German Breast Group Forschungs GmbH, Frankfurt, Germany

3:00 PM - 3:30 PM Topic 2: Positioning and sequencing of ADCs in metastatic breast cancer

• Reshma Mahtani, DO, Miami Cancer Institute, Miami

3:30 PM - 4:00 PM Topic 3: Activity of ADCs in patients with brain metastases

• Andrew Brenner, MD, PhD, UT Health San Antonio

Patient Advocate: Rosa Olmos, Barcelona, Spain 

Panel Q&A

Educational Session 7: Immune Microenvironment
Location: Hemisfair Ballrooom 3

Moderator: Charles Perou, PhD , Lineberger Comprehensive Cancer Center University of North Carolina

2: 30 - 3:00 PM Topic 1: Immune cell changes across the lifespan in ER+ breast cancers

• TBD

3:30 - 3:30 PM Topic 2: Immune system role in early onset breast cancer

• Virginia Borges, MD, UCHealth Diane O’Connor Thompson Breast Center – Anschutz Medical Campus, Aurora, Colorado

3:30 PM - 4:00 PM Topic 3: Glucocorticoid and T-cell receptors in breast cancer

•  Suzanne Conzen, MD, UT Southwestern, Dallas

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Ghecemy Lopez, DSW, MAED, USC Norris Comprehensive Cancer Center, Los Angeles

Educational Session 8: Optimizing De-escalation in Low-Risk HR+ Early-Stage Breast Cancer
Location: Stars at Night 3 & 4

Moderator: Mylin Torres, MD, Winship Cancer Institute of Emery University, Atlanta

2:30 PM - 3:00 PM Topic 1: Advances in Breast Radiotherapy – Less is More

• Jonathan Strauss, MD, MBA, Roberts H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

3:00 PM - 3:30 PM Topic 2: Radiation therapy or Endocrine therapy – which one to omit?

• Icro Meattini, MD, University of Florence, Florence, Italy

3:30 PM - 4:00 PM Topic 3: What do we do with the nodes?

• Tari King, MD, FACS, Dana-Farber Cancer Institute, Boston

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Marylinn Minor, Virginia Breast Cancer Foundation Board Member

Educational Session 9: Management for Predisposition Gene Carriers
Location: 221 ABC

Moderator: Susan Domchek, MD, University of Pennsylvania Perelman School of Medicine, Philadelphia

2:30 PM - 3:00 PM Topic 1: Overview of genetic risk models

• Tuya Pal, MD, Vanderbilt-Ingram Cancer Center, Nashville

3:00 PM - 3:30 PM Topic 2: Interpretation of inherited alterations in high and moderate risk genes

• Fergus Couch, PhD, Mayo Clinic, Rochester, Minnesota

3:30 PM - 4:00 PM Topic 3: Clinical management of predisposition gene carriers

• Stephanie Wong, MD, MPH, McGill Medical School, Montreal

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Bri Wesley-Majsiak, Co-founder of The Breasties, Los Angeles

Educational Session 10: Rare Tumor Types
Location: Hemisfair Ballroom 1 & 2

Moderator: William Gradishar, MD, Northwestern University Feinberg School of Medicine, Chicago

2:30 PM - 3:00 PM Topic 1: How to optimally treat Phyllodes tumors 

• Lauren Rosenberger, MD, MS, Duke University Cancer Institute, Durham, North Carolina

3:00 PM - 3:30 PM Topic 2: Pathological Characterization of Rare tumor types

• TBD

3:30 PM - 4:00 PM Topic 3: Metaplastic Breast Cancer

• Jenny Chang, MD, Houston Methodist Neal Cancer Center, Houston

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: TBD

Rapid Fire 3
Location: Stars at Night 1 & 2

Women's Career Development Workshop
Location: 221ABC

Speaker: Anne Welsh

Poster Session 2
Location: Exhibition Hall