(All times are in Central Standard Time)

Ancillary Educational Events
(In-person only, not available for online or virtual viewing)

Lillly Advocate Program
Location: Room 220

ABC Global Alliance Ten Year Breast Cancer Report The Do's & Don'ts of Communication on Advanced/Metastatic Breast Cancer
Location: Room 221ABC

SABCS Program Begins

Career Development Workshop - Real World Research: Building Your Community
Location: TBD

Keynote: Clifford Hudis, MD, CEO of American Society of Clinical Oncology, Alexandria, Virginia

Topics: TBD

Special Session 1: Open Bar and All You Can Eat? The Impact of Lifestyle in Breast Cancer Risk and Recurrence

Location: Stars at Night 1 & 2

Moderator: Seema Khan, MD, MS, Northwestern University Feinberg School of Medicine, Chicago

11:00 AM -11:25 AM - Topic 1: Genetics of alcohol metabolism and breast cancer risk

• Speaker: Julia Palmer, ScD, Boston University, Boston

11:25 AM -11:55 AM - Topic 2: Effects of alcohol consumption and cessation on breast cancer risk

• Speaker: Mary Beth Terry, PhD, Columbia University, New York

11:55 AM-12:15 PM - Topic 3: Obesity and Breast Cancer- the molecular link

• Speaker: Kristy Brown, PhD, University of Kansas Medical Center, Kansas City, Kansas

Patient Advocate: Stacey Tinianov, MPH, BCPA, Advocates for Collaborative Education, Santa Cruz, California

12:15 PM-12:30 PM  Panel Q&A

Special Session 2: Lobular Breast Cancer Updates
Location: Stars at Night 3 & 4

11:00 AM – 11:10 Moderator Introduction: Steffi Oesterreich, PhD, UPMC Hillman Cancer Center, Pittsburgh & Marleen Kok, MD, PhD, Netherlands Cancer Institute, Amsterdam

11:10 AM – 11:25 Topic 1: Current updates on diagnostic criteria and classification of special subtypes

• Speaker: Anne Vincent-Salomon, PhD, Institut Curie, Paris

11:25 AM – 11:40 AM Topic 2: Novel biomarkers with clinical implications

• Speaker: Christos Sotiriou, MD, PhD, Institut Jules Bordet, Anderlecht, Belgium

11:40 AM – 11:55 AM Topic 3: Controversies in clinical decision making – is there still a role for chemotherapy?

• Speaker: Otto Metzger, MD, Dana-Farber Cancer Institute, Boston

11:55 AM – 12:10 PM Topic 4: ILC-specific trials: lessons learned and future designs

• Speaker: Philipe Aftimos, MD, Insitut Jules Bordet, Anderlecht, Belgium

12:10 PM – 12: 30 PM Panel discussion

Patient Advocate: Flora Migyanka, BA, Seattle Genetics

Special Session 3: Breast Cancer in Young Women: Biology, Treatment, and Ethics
Location: TBD

Moderator: Ann Partridge, MD, MPH, Dana-Farber Cancer Institute, Boston

Topic 1: Epidemiology and Biology of Young Onset Breast Cancer

• Speaker: Virginia Borges, MD, UCHealth Diane O’Connor Thompson Breast Center – Anschutz Medical Campus, Aurora, Colorado

Topic 2: Special Management Considerations for Young Patients with Breast Cancer

• Speaker: Yara Abdou, MD, MSCR, UNC Lineberger Comprehensive Cancer Center, Chappel Hill, North Carolina

Topic 3: Ethical Issues in the Care of Young Patients with Breast Cancer

• Speaker: TBD

Translational Workshop 1: Spatial Omics for Prediction, Prognostication, and Mechanistic Insights
Location: Hemisfair Ballroom 1-2

Moderator: Leif Ellisen, MD, PhD, Harvard University, Cambridge, Massachusetts

12:45 PM – 1:10 PM Topic 1: Proteomics

• Speaker: Sandro Santagata, MD, PhD, Harvard Medical School, Cambridge, Massachusetts

1:10 PM – 1:35 PM Topic 2: Metabolomics+

• Speaker: Ralph Deberardinis, MD, PhD, UT Southwestern, Dallas

1:35 PM – 2:00 PM Topic 3: Gylcocomics

2:00 PM – 2:15 PM Panel discussion

 Patient advocate: Jane Perlmutter, PhD, MBA

Translational Workshop 2: Liquid Biopsy in Breast Cancer, Bridging Technology and Clinical Practice
Location: Stars at Night 1-2

Moderator: Pedram Razavi, MD, PhD, Memorial Sloan Kettering Cancer Center, New York

12:45 PM – 1:10 PM Topic 1: Emerging technologies in liquid biopsy, Maximilian Diehn, MD, PhD, Stanford University, Stanford, California

1:10 PM – 1:35 PM Topic 2: Expanding clinical application of liquid biopsy in breast cancer, Pedram Razavi, MD, PhD, Memorial Sloan Kettering Cancer Center, New York 

1:35 PM - 2:00 PM Topic 3: 

2:00 PM - 2:15 PM Panel discussion

 Patient advocate: Judy Fitzgerald

Clinical Workshop 1: Risk Assessment and Management in Young Women
Location: Stars at Night 3-4

12:45 PM – 12:55 PM Moderator Introduction: Sonya Reid, MD, MPH, Vanderbilt-Ingram Cancer Center, Nashville

12:55 PM – 1:10 PM Topic 1:

1:10 PM – 1:25 PM Topic 2: Novel imaging strategies for young women – looking to the future

• • Emily Conant, MD, University of Pennsylvania Perelman School of Medicine, Philadelphia

1:25 PM – 1:40 PM Topic 3:

1:40 PM – 1:55 PM Topic 4:

1:55 PM – 2:15 PM Panel discussion

Patient Advocate: Vernal Branch, Independent Research Patient Advocatie, Richmond, Virginia

Educational Session 1: After CDK4/6 Inhibitors: Advancing Treatment for HR+HER2-negative Metastatic Breast Cancer
Location: Stars at night 1-2

Moderator: Antoinette Tan, MD, MHS, Wake Forest University School of Medicine, Charlotte, North Carolina

2:30 PM – 3:00 PM Topic 1: Treatment Strategies after CDK4/6 Inhibitor Progression

• • Speaker: Mafalda Oliveira, MD, PhD, Vall d'Hebron Hospital, Barcelona

3:00 PM – 3:30 PM Topic 2: Next Generation Endocrine Agents

• • Speaker: Erica Mayer, MD, MPH, Dana-Farber Cancer Institute, Boston

3:30 PM – 4:00 PM Topic 3: Emerging Agents to Overcome CDK4/6 Inhibitor Resistance

• • Speaker Shom Goel, PhD, FRACP, Peter MacCallum Cancer Centre, Melbourne, Australia

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Abigail Johnston, SurvivingBreastCancer.org, Orlando, Florida

Educational Session 2: Dormancy and Re-activation of Breast Cancer Cells at Distant Metastatic Sites
Location: 221 ABC

Moderator: Heide Ford, PhD, University of Colorado School of Medicine, Denver

2:30 PM-3:00 PM - Topic 1: Viral reactivation of dormant breast cancer

• • Speaker: Mercedes Rincon, PhD, University of Colorado School of Medicine, Aurora, Colorado

3:00 PM-3:30 PM Topic 2: Role of alveolar macrophages in dormancy

• • Speaker: Xue-Yan He, PhD, Washington University in St. Louis

3:30 PM - 4:00 PM Topic 3: In vivo mechanisms regulating cellular dormancy and tumor recurrence

• • Speaker: Lewis Chodosh, PhD, University of Pennsylvania Perelman School of Medicine, Philadelphia
  • 4:00 PM - 4:15 PM Panel Q&A

4:00 PM - 4:15 PM Panel Discussion

Patient Advocate: Lynda Weatherby, Metastatic Breast Cancer Alliance, Seattle

Educational Session 3: Refining Local Therapy in Multi-disciplinary Care
Location: Stars at Night 3-4

Moderator: Jonathan Strauss, MD, MBA, Roberts H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

2:30 PM-3:00 PM Topic 1: Repeat Breast Conservation with reirradiation – what’s the data and how do we do it?

• • Speaker: Chelain Goodman, MD, PhD, MD Anderson Cancer Center, Houston

3:00 PM-3:30 PM Topic 2: Should we irradiate the IM Nodes: Settling the Issue

• • Speaker: Birgitte Offersen, MD,  Aarhus University Department of Oncology, Aarhus, Denmark

3:30 PM - 4:00 PM Topic 3: The Truth About Radiotherapy and Reconstruction

• • Speaker: Justin Broyles, MD, Brigham and Women’s Hospital, Boston

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Judy Fitzgerald, Sisters4Prevention, Delray Beach, Florida

Educational Session 4: Balancing Act: Hormone Replacement Therapy in Breast Cancer Care
Location: Hemisfair Ballroom 1-2

Moderator: Tara Sanft, MD, Yale School of Medicine, New Haven, Connecticut

2:30 PM - 3:00 PM Topic 1: "HRT and Breast Cancer: How History Shaped Fear and What Comes Next" Re-examining past research, debunking myths, and guiding future recommendations

• • Speaker: Maryam Lustberg, MD, MPH, Yale School of Medicine, New Haven, Connecticut

3:00 PM - 3:30 PM Topic 2: "Navigating the Latest HRT Guidelines: What Leading Medical Societies Say" A comprehensive review of updated recommendations from major health organizations.

• • Speaker: Juliana Kling, MD, MPH, MACP, MSCP, Mayo Clinic, Phoenix

3:30 PM - 4:00 PM Topic 3: "HRT Across the Breast Cancer Spectrum: Risks, Benefits, and Considerations" Exploring HRT use in high-risk individuals, survivors, and different breast cancer subtypes.

• • Speaker: Lisa Larkin, MD, FACP, MSCP, Ms. Medicine/HERmedicine, Cincinnati, Ohio

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Thelma Perry Brown, BS, Patient Research Advocate, Birmingham, Alabama

Educational Session 5: Best of AACR
Location: Hemisfair Ballroom 3

2:30 PM – 3:00 PM Topic 1:

3:00 PM – 3:30 PM Topic 2:

3:30 PM – 4:00 PM Topic 3:

Late Breaking Abstracts
Location: Stars at Night 1-2

8-minute abstract presentations

Refreshment Break and Networking
Location: TBD

Clinical Trial Updates
Location: Stars at Night 1-2

8-minute abstract presentations

(All times are in Central Standard Time)

Poster Spotlight 1
Location: Hemisfair Ballroom 3

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30-7:50

Panel Q&A 1: 7:50-8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20-8:30

Poster Spotlight 2
Location: 301 ABC

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30-7:50

Panel Q&A 1: 7:50-8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20-8:30

Location: 302 ABC

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30-7:50

Panel Q&A 1: 7:50-8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20-8:30

Location: 221 ABC

Moderator:

7:00 AM - 7:30 Poster viewing

Subtopic 1: 7:30-7:50

Panel Q&A 1: 7:50-8:00

Subtopic 2: 8:00 - 8:20

Panel Q&A 2: 8:20-8:30

General Session 1
Location: Hall 1

8:45 - Opening Remarks from Symposium Co-Chairs Dr. Carlos Arteaga and Dr. Virginia Kaklamani

9:00 - McGuire Award presentation and lecture (announcement coming soon)

9:30 am - 12:00 pm 15-minute Oral Presentations

Exhibition Hall Open

Break

Clinical Case Discussion
Location: Stars at Night 1 & 2

Moderator: Monica Morrow, MD, FACS, Memorial Sloan Kettering Cancer Center, New York

Poster Session 1
Location: Exhibition Hall

State of the Art 1 - Liquid Biopsy for Adaptive Therapy in Breast Cancer
Location: Stars at Night 1 & 2

1:00 PM – 1:10 PM Moderator (Introduction) - David Cescon, MD, Princess Margaret Cancer Centre, Toronto 

Topic 1: Neoadjuvant adaptive strategies: integrating imaging and ctDNA to personalize preoperative therapy

• • Speaker: Angie DeMichele, MD, MSCE, University of Pennsylvania Perelman School of Medicine, Philadelphia

Topic 2: MRD-Informed Adjuvant Therapy: From Risk Stratification to Personalized Management

• • Speaker: Michail Ignatiadis, MD, PhD, Institut Jules Bordet, Anderlecht, Belgium

Topic 3: Guiding Metastatic Breast Cancer Treatment with Dynamic and Predictive Liquid Biopsy Biomarkers

• • Speaker François-Clément Bidard, MD, PhD, Institut Curie, Paris

Patient Advocate: Barbara Segarra-Vazquez, D.H.Sc., University of Puerto Rico School of Health Professions, San Juan, Puerto Rico

Translational Controversies
Location: Stars at Night 3 & 4

Moderator: David Rimm, MD, PhD, Yale School of Medicine, New Haven, Connecticut

Topic 1: HER2 low/ultralow; What the pathologist sees

• • Speaker: Dennis Sgroi, MD, Harvard University, Cambridge, Massachusetts

Topic 2: Evidence that ADCs are target therapy

• • Speaker: Sarat Chandarlapaty, MD, PhD, Memorial Sloan Kettering Cancer Center, New York

Topic 3: Evidence that ADCs are chemotherapy

Speaker: Sara Hurvitz, MD, FACP , Fred Hutchinson Cancer Center, Seattle, Washington                

Educational Session 6: ADCs in the Clinic

Location: Stars at Night 1 & 2

Moderator: Adrienne Waks, MD, Dana-Farber Cancer Institute, Boston

Topic 1: Moving on up: ADCs in early - stage breast cancer

• • Speaker: Sibylle Loibl, MD, CEO of the German Breast Group Forschungs GmbH, Frankfurt, Germany

Topic 2: Positioning and sequencing of ADCs in metastatic breast cancer

• • Speaker: Reshma Mahtani, DO, Miami Cancer Institute, Miami

Topic 3: Activity of ADCs in patients with brain metastases

• • Speaker: Andrew Brenner, MD, PhD, UT Health San Antonio

Patient Advocate: Rosa Olmos, Barcelona, Spain 

Educational Session 7: Immune Microenvironment
 

Location: Hemi 3

Moderator: Charles Perou, PhD , Lineberger Comprehensive Cancer Center University of North Carolina

2: 30 – 3:00 PM Topic1: Immune cell changes across the lifespan in ER+ breast cancers

• • Speaker: Sandra McAllister, PhD, Harvard Medical School and Brigham and Women’s Hospital, Boston

3:30 – 3:30 PM Topic 2: Immune system role in early onset breast cancer

• Speaker: Virginia Borges, MD, UCHealth Diane O’Connor Thompson Breast Center – Anschutz Medical Campus, Aurora, Colorado
• Traci Lyons, PhD, University of Colorado Anschutz Medical Campus, Aurora, Colorado

3:30 PM – 4:00 PM Topic 3: Glucocorticoid and T-cell receptors in breast cancer

• • Speaker: Suzanne Conzen, MD, UT Southwestern, Dallas

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Ghecemy Lopez, DSW, MAED, USC Norris Comprehensive Cancer Center, Los Angeles

Educational Session 8: Optimizing De-escalation in Low-Risk HR+ Early-Stage Breast Cancer
Location: Stars at Night 3 & 4

Moderator: Mylin Torres, MD, Winship Cancer Institute of Emery University, Atlanta

2:30 PM-3:00 PM Topic 1: Advances in Breast Radiotherapy – Less is More

Speaker: Jonathan Strauss, MD, MBA, Roberts H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

3:00 PM-3:30 PM Topic 2: Radiation therapy or Endocrine therapy – which one to omit?

• • Speaker: Icro Meattini, MD, University of Florence, Florence, Italy

3:30 PM - 4:00 PM Topic 3: What do we do with the nodes?

• • Speaker: Tari King, MD, FACS, Dana-Farber Cancer Institute, Boston

4:00 PM - 4:15 PM Panel Q&A

• Patient Advocate: Ivis Febus-Sampayo,  NBCC Board of Directors; and SHARE, New York

Educational Session 9: Management for Predisposition Gene Carriers
Location: TBD

Location: 221 ABC

Moderator: Susan Domchek, MD, University of Pennsylvania Perelman School of Medicine, Philadelphia

2:30 PM-3:00 PM Topic 1: Overview of genetic risk models

• • Speaker: Tuya Pal, MD, Vanderbilt-Ingram Cancer Center, Nashville

3:00 PM-3:30 PM Topic 2: Interpretation of inherited alterations in high and moderate risk genes

• • Speaker: Fergus Couch, PhD, Mayo Clinic, Rochester, Minnesota

3:30 PM - 4:00 PM Topic 3: Clinical management of predisposition gene carriers

• • Speaker: Stephanie Wong, MD, MPH, McGill Medical School, Montreal

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Bri Wesley-Majsiak, Co-founder of The Breasties, Los Angeles

Educational Session 10: Rare Tumors
Location: Hemi 1 & 2

Moderator: William Gradishar, MD, Northwestern University Feinberg School of Medicine, Chicago

2:30 PM-3:00 PM Topic 1: How to optimally treat Phyllodes tumors 

• • Speaker: Lauren Rosenberger, MD, MS, Duke University Cancer Institute, Durham, North Carolina

3:00 PM-3:30 PM Topic 2: Pathological Characterization of Rare tumor types

• • Speaker: Stuart J. Schnitt, MD, Dana-Farber Cancer Institute, Boston

3:30 PM - 4:00 PM Topic 3: Metaplastic Breast Cancer

• • Speaker: Jenny Chang, MD, Houston Methodist Neal Cancer Center, Houston

4:00 PM - 4:15 PM Panel Q&A

Patient Advocate: Laura Houmes, Metaplastic Breast Cancer Global Alliance, Viera, Florida

Rapid Fire 1
Location: Stars at Night 1 & 2

Poster Session 2
Location: Exhibition Hall